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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Metformin
supplement:
Progestins
Research Papers that Mention the Interaction
“In addition, brusatol and metformin overcame progestin resistance by down-regulating Nrf2/AKR1C1 expression.”
“Patients with elevated HbA1C receiving both metformin and progestin were more likely to achieve CR, whereas those with PCOS were not.”
“Even though 75% … rate in metformin … oral progestin group is relatively unsatisfactory compared to reported result in treatment of atypical EH with LNG-IUS, the present study is meaningful … being the first clinical trial that has evaluated the efficacy of metformin plus oral progestin for treatment of atypical EH.”
“ Metformin and oral contraceptives could be an alternative treatment in the presence of progestin resistance.”
Reverse of Progestin-Resistant Atypical Endometrial Hyperplasia by Metformin and Oral Contraceptives“Interestingly, metformin increased the progestin sensitivity by down regulation of Nrf2 and survivin.”
Mechanism of progestin resistance in endometrial precancer/cancer through Nrf2-survivin pathway.
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