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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Metformin
supplement:
Palmitic Acid
Research Papers that Mention the Interaction
“METHODS AND RESULTS We observed that me formin si gnificantly reduced intracellular ROS levels induced by PA. ”
Metformin reduces intracellular reactive oxygen species levels by upregulating expression of the antioxidant thioredoxin via the AMPK-FOXO3 pathway.“METHODS AND RESULTS We observed that me formin si gnificantly reduced pal mitic acid (P A)-induced intracellular lipid accumulation in macrophages.”
“ResultsIncubation of myocytes with palmitic acid for 16 h increased apoptosis, an effect that was partly blunted by 1 and 2 mmol/l metformin.”
“We hypothesised that metformin could prevent both caspase-3 activation and apoptosis when induced by palmitic acid.”
Metformin influences cardiomyocyte cell death by pathways that are dependent and independent of caspase-3
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