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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Metformin
supplement:
Multivitamin Preparation
Research Papers that Mention the Interaction
“Among the participants with diabetes who were on metformin therapy, multivitamin use was associated with geometric mean serum vitamin B12 concentrations that were 50% (or 161 pmol/L) higher, compared to those not using multivitamins.”
“Among metformin users, multivitamin use was associated with lower prevalence of combined low and borderline vitamin B12 concentrations (aOR = 0.14; 95% CI = 0.04, 0.54) compared to those not using multivitamins.”
“Concurrent multivitamin use may potentially protect against low or borderline vitamin B12 concentrations in long-term metformin users.”
Multivitamin Use and Serum Vitamin B12 Concentrations in Older-Adult Metformin Users in REGARDS, 2003-2007“… metformin had lower serum B12 levels (425.99 pg/mL vs 527.49 pg/mL; P = .012) and were at increased risk …), as defined by a serum B12 level <350 pg/mL. Prevalence of B12 deficiency was significantly lower for patients using a multivitamin (odds ratio, 0.…–0.63).”
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