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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Metformin
supplement:
Methionine
Research Papers that Mention the Interaction
“Additionally, unbiased metabolomics studies have provided strong evidence to support that metformin alters the methionine and folate cycles, with a concomitant decrease in nucleotide synthesis.”
Metformin and cancer: Between the bioenergetic disturbances and the antifolate activity.“To understand how metformin limits folate in bacteria, the authors investigated methionine metabolism and found that metformin impaired the methionine cycle and was associated with increased levels of both S-adenosylmethionine (SAMe) and S-adenosylhomocysteine (SAH).”
“We report that metformin increases lifespan by altering microbial folate and methionine metabolism.”
“EVO + MET slightly reduced steady state maximum concentration and area under the concentration–time curve at steady state values for metformin compared to MET, with geometric mean ratios (90% confidence interval) of 0.84 (0.79–0.89) and 0.94 (0.89–0.98), respectively.”
“In … receiving metformin therapy, arginine-… and methionine sulfoxide were lower than in patients not receiving metformin: 19.3 vs. 8.9 mol% (P < 0.01) and 2.9 …. 1.9 mol% (P < 0.05), respectively; 3-nitrotyrosine content was higher: 0.10 vs. 0.03 mol% (P < 0.05).”
“In addition, sulfonylurea or metformin monotherapy was associated with a 36% higher compliance rate than M + S polytherapy (177 days vs 130 days).”
“In contrary, co‐treatment with Methionine and Met reduced the detrimental effect of Methionine.”
“In contrary, co‐treatment with methionine and Met reduced the detrimental effect of methionine.”
“Treatment of THP‐1 and raw264.7 cells with methionine and Met reduced the activity of methionine in dose dependently.”
Administration of metformin alleviates atherosclerosis by promoting H2S production via regulating CSE expression“In conclusion, the genetic variants of OCT2 (OCT2-T199I, -T20 M , and -A270S) decreased the transport activity of metformin and thus may contribute to the inter-individual variation in metformin disposition as OCT2 plays a pivotal role in renal excretion, the major disposition route of metformin.”
“In all sensitive cells, metformin decreased the Δψ m and it modified the expression of enzymes involved in energy metabolism: PKCε (PKCepsilon) and PKCδ (PKCdelta).”
Metformin Induces Cell Cycle Arrest and Apoptosis in Drug-Resistant Leukemia Cells“In conclusion, L-methionine induced memory impairment, and treatment with metformin prevented this impairment probably by normalizing oxidative stress in the hippocampus.”
“In the current study, we tested if chronic metformin administration prevents memory impairment induced by administration of L-methionine.”
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