Possible Interaction: Metformin and Ginseng

“Certain NAX compounds may interact with WT-TP53 and metformin treatment to alter the expression of key molecules involved in cell growth.”

“Upon restoration of WT-TP53 activity in MIA-PaCa-2 cells, an altered sensitivity to the combination of certain NAX compounds and metformin was observed compared to the parental cells which normally lack WT-TP53.”

“In conclusion, repeated administration of RGE showed in vivo pharmacokinetic herb–drug interaction with metformin , with regard to its plasma exposure and increased absorption in rats.”

“ RGE repeated dose also increased the intestinal permeability of metformin ; however, the permeability of 3-O-methyl-d-glucose and Lucifer yellow was not changed in 1WRA rats, suggesting that the increased permeability of metformin by multiple doses of RGE is substrate-specific.”

“Repeated doses of RGE for 1 week significantly increased the plasma concentration of metformin , with increased half-life and urinary excretion of metformin following oral administration of metformin (50 mg/kg), which could be attributed to the increased absorption of metformin.”

“These results were consistent with increased intestinal Oct1 and its functional consequence, therefore, the combined therapeutic efficacy needs further evaluation before the combination and repeated administration of RGE and metformin , an Oct1 substrate drug.”