Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Metformin and Folate

supplement:

Folate

Research Papers that Mention the Interaction

Some aspects of the response to folate may be different in patients on metformin.
Diabetes, nutrition & metabolism  •  2004  |  View Paper
In conclusion, metformin treatment increased tHcy levels and decreased levels of vitamin B12 and folate.
Scandinavian journal of clinical and laboratory investigation  •  1997  |  View Paper
Additionally, unbiased metabolomics studies have provided strong evidence to support that metformin alters the methionine and folate cycles, with a concomitant decrease in nucleotide synthesis.
Pharmacological research  •  2015  |  View Paper
The authors probed potential bacterial metabolic pathways whose disruption is known to increase longevity and found that metformin reduced the amount of bioavailable folate.
Nature Medicine  •  2013  |  View Paper
We report that metformin increases lifespan by altering microbial folate and methionine metabolism.
Cell  •  2013  |  View Paper
Metformin can decrease vitamin B12 and folate concentrations.
The Journal of clinical endocrinology and metabolism  •  2020  |  View Paper
CONCLUSIONS Metformin exerts a slight but significant deleterious effect on serum Hcy levels in patients with PCOS, and supplementation with folate is useful to increase the beneficial effect of metformin on the vascular endothelium.
OBJECTIVE To evaluate whether the administration of metformin exerts any effects on serum homocysteine (Hcy) levels in patients with polycystic ovary syndrome (PCOS) and whether supplementation with folate enhances the positive effects of metformin on the structure and function of the vascular endothelium.
Diabetes Care  •  2009  |  View Paper
Lowered levels of vitamin B12 and folate due to impaired gastrointestinal absorption have been documented with long-term metformin therapy,1 but clinically these effects are insignificant and do not cause anaemia.
Postgraduate medical journal  •  2000  |  View Paper
Metformin has another side effect, namely interference with vitamin B12 and folate metabolism, leading to elevated homocysteine serum levels.
Dermato-endocrinology  •  2013  |  View Paper