Possible Interaction: Metformin and Calcium Supplement

“We demonstrate that metformin induces endoplasmic reticulum (ER) stress, calcium release from the ER and subsequent uptake of calcium into the mitochondria, thus leading to mitochondrial swelling.”

“ CAC severity and presence were significantly lower among men in the metformin versus the placebo group (age-adjusted mean CAC severity, 39.5 versus 66.9 Agatston units, P=0.04; CAC presence, 75% versus 84%, P=0.02), but no metformin effect was seen in women.”

“In addition, metformin prevented to a significant extent mitochondrial permeability transition both in permeabilized cells, as induced by calcium , and in intact cells, as induced by the glutathione-oxidizing agent t-butyl hydroperoxide.”

“Furthermore, metformin regulated calcium ion homeostasis to relieve ER-stress and inhibited release of mitochondrion apoptosis factors (BAD and caspase).”

“In female rat aortic … (RASMCs), we observed that metformin significantly alleviated …-induced Ca deposition and alkaline phosphatase activity, corresponding with reduced expression of some specific genes in osteoblast-like cells, including … bone morphogenetic protein-2, and positive effects on α-actin expression, a specific marker of smooth muscle cells.”

“Overall, these results verify that metformin could shorten a prolonged QT interval by inhibiting the calcium current, suggesting that metformin may play a role in the electrophysiology underlying diabetic cardiopathy.”

“Conclusion Changes in CA synthesis after metformin treatment may be associated with inhibition of CYP8B1.”

“Calcium imaging using fluo-4 showed that metformin (100 µM) inhibited the intracellular calcium increase that was induced by QUIN.”