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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Metformin
supplement:
Asymmetric Dimethylarginine
Research Papers that Mention the Interaction
“In this study, metformin treatment leads to improvement in hormonal and metabolic parameters and decreases ADMA and homocysteine levels possibly independent of BMI.”
Inflammatory-metabolic parameters in obese and nonobese normoandrogenemic polycystic ovary syndrome during metformin and oral contraceptive treatment“Moreover, in the subgroup of women treated with metformin, ADMA levels decreased significantly independent of a reduction in BMI, with a concurrent improvement in carotid intima-media thickness (IMT).These latterresults,althoughof interest, shouldbeexamined with caution because the number of women receiving metformin wassmall (n 21),anddurationof treatmentwasshort.”
“Does treatment with metformin , which has a potential effect on the inhibition of glycation reactions in vivo, decrease the levels of ADMA in diabetic patients?”
“ Metformin decreased tissue ADMA level while it restored the DDAH activity and GSH.”
Antidiabetic drug metformin is effective on the metabolism of asymmetric dimethylarginine in experimental liver injury.“There is only one direct study that shows that ADMA negates the metabolic effects of metformin.”
The ADMA-Metformin Hypothesis: Linking the Cardiovascular Consequences of the Metabolic Syndrome and Type 2 Diabetes.
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