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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Metformin
supplement:
Adrenocorticotropic Hormone
Research Papers that Mention the Interaction
“CONCLUSION(S) The administration of me formin to unselected women with PCOS led to a reduction in the adrenal steroidogenesis response to ACT H. ”
“The administration of metformin was associated with a significant reduction in the response of 17alpha-hydroxyprogesterone, testosterone, free testosterone, and androstenedione to ACTH.”
Effects of metformin on adrenal steroidogenesis in women with polycystic ovary syndrome.“Moreover, metformin therapy is associated with attenuation of the adrenal steroidogenic response to ACTH.”
“Our study may explain how metformin helps in weight loss and attenuates the excess response to ACTH in androgen excess disorders such as PCOS and CAH.”
“Recent studies have shown that metformin decreases ACTH secretion from pituitary and reduces ACTH-stimulated adrenal secretion.”
“The ACTH concentration response curve (CRC) was half-log shifted and a ∼30% reduction in maximum receptor response (Rmax) to ACTH in presence of metformin was observed.”
“This effect was dose dependent with an IC50 of 4.2 mM. qRT-PCR analyses showed that metformin decreased ACTH induced MC2R expression.”
“We found a significant inhibition of ACTH induced MC2R activation and signaling with 10 mM metformin.”
Metformin inhibits the activation of melanocortin receptors 2 and 3 in vitro: A possible mechanism for its anti-androgenic and weight balancing effects in vivo?
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