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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Mersalyl
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“In OCa-EGTA-ghosts the amount of Ca taken up into the intracellular space was markedly increased by the addition of mersalyl (0.05mm) to the external medium.”
ATP-independent calcium net movements in human red cell ghosts“ Mersalyl inhibited Ca uptake in both mitochondria and microsomes.”
“Deenergized mitochondria incubated in the presence of Ca2+ (0-500 microM) undergo a very significant decrease in the content of membrane protein thiols accessible to NEM, and an increase in the content of thiols accessible to mersalyl.”
Mitochondrial membrane protein thiol reactivity with N-ethylmaleimide or mersalyl is modified by Ca2+: correlation with mitochondrial permeability transition.“ Calcium uptake into intact sperm is highly inhibited by mersalyl and this inhibitory effect can be completely relieved when the plasma membrane is disrupted by filipin.”
“ Ca uptake rate is linear with time over much of its course, can be switched on/off by the addition/withdrawal of Ca2+, ATP, or oxalate to/from the medium, and is inhibited by mersalyl and tetracaine.”
“ Ca++ uptake is inhibited by uncoupling agents, respiratory inhibitors, ruthenium red, and the mercurials mersalyl and p-mercuribenzoate.”
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