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Discover Supplement-Drug Interactions

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Last Updated: 5 months ago

Possible Interaction: Meropenem and Serum Albumin, Human

Research Papers that Mention the Interaction

CD spectroscopy showed a change in the conformation of both the isoforms of HSA upon meropenem binding.
Electrostatic interactions and van der Waal interactions along with H-bonds stabilized the complex of meropenem with 'N' and 'B' isoforms of HSA , respectively.
Molecular docking results revealed that meropenem binds to HSA near Sudlow's site II (subdomain IIIA) close to Trp-214 with a contribution of a few residues of subdomain IIA.
Results showed that meropenem quenches the fluorescence of both 'N' and 'B' isoforms of HSA (ΔG < 0 and binding constant ~10(4) M(-1)).
Journal of biomolecular structure & dynamics  •  2016  |  View Paper