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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Meropenem
supplement:
Serum Albumin, Human
Research Papers that Mention the Interaction
“Addition of meropenem plus 3.5% HSA caused synergistic enhancement of natural transformation in A. baumannii A118.”
Interplay between Meropenem and Human Serum Albumin on Expression of Carbapenem Resistance Genes and Natural Competence in Acinetobacter baumannii“CD spectroscopy showed a change in the conformation of both the isoforms of HSA upon meropenem binding.”
“Electrostatic interactions and van der Waal interactions along with H-bonds stabilized the complex of meropenem with ‘N’ and ‘B’ isoforms of HSA , respectively.”
“Molecular docking results revealed that meropenem binds to HSA near Sudlow’s site II (subdomain IIIA) close to Trp-214 with a contribution of a few residues of subdomain IIA.”
“Results showed that meropenem quenches the fluorescence of both ‘N’ and ‘B’ isoforms of HSA (ΔG < 0 and binding constant ~104 M−1).”
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