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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Mercaptopurine
supplement:
S-Adenosylmethionine
Research Papers that Mention the Interaction
“In addition to TPMT genotyping, SAM may serve as an important biochemical marker in individualization of thiopurine therapy.”
Post-translational stabilization of thiopurine S-methyltransferase by S-adenosyl-L-methionine reveals regulation of TPMT*1 and *3C allozymes.“Identification of SAM as critical modulator of TPMT activity and consequently thiopurine toxicity may set novel grounds for the rationalization of thiopurine therapy.”
“We thus propose that SAM reverses the extent of 6-MP cytotoxicity, by acting as a TPMT-stabilizing factor.”
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