supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
drug:
Mercaptopurine
supplement:
Inosine
Research Papers that Mention the Interaction
“Adenosine, deoxyadenosine, inosine , and deoxyinosine completely prevented the toxic action of the purinethiol , while guanosine and deoxyguanosine were only partially effective.”
“Finally, we also demonstrate for the first time an up-regulation by azathioprine and 6-mercaptopurine of inosine monophosphate dehydrogenase which might have consequences on the de novo biosynthesis of guanine nucleotides and thiopurines metabolism.”
Differential toxic effects of azathioprine, 6-mercaptopurine and 6-thioguanine on human hepatocytes.“ 6-MP inhibitory effects on the MLR were reversed by AIC (46%), adenine (32%), hypoxanthine (89%), adenosine (86%) and inosine (93%).”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback