Possible Interaction: Mercaptopurine and Glutathione

“…,glutathione plays a role in the detoxification and repair of cellular … by such diverse agents as mechlorethamine, melphalan, cyclophosphamide, nitrosoureas, 6-thiopurine , 4'-(9-acridinylamino)methanesulfon-m-anisidide, the quinone antibiotics (including Adriamycin, daunorubicin, and mitomycin …), the sesquiterpene lactones (such as vernolepin), and other sulfhydryl-reactive diterpenes (like jatrophone).”

“In the presence of thiols such as glutathione , the irreversible protein binding of 6-thiopurine was inhibited.”

“Thiol-containing drugs such as captopril and 6-mercaptopurine loaded within DEGNPs showed an "Off-On" release behavior in the presence of thiol-reducing agents such as glutathione and dithiothreitol.”

“ Glutathione levels increased when exposed to high MP concentrations but decreased when co-exposed to Cd.”

“The cumulative release of 6-MP was less than 3% in absence of GSH, and reached more than 70% within 2h in the presence of 3mM GSH.”

“ Glutathione (GSH) depresses the 6-MP level in plasma; a dose of 10 mg/kg of GSH elevates the concentration in shallow peripheral compartment and prolongs t0.5.”

“The results indicate that 6-MP distribution in the body may be changed by GSH .”

“ Glutathione protects against protein binding of the 6-thiopurine metabolite.”

“ GSH activity was only significantly increased after MP exposure for 5 days.”