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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Mercaptopurine
supplement:
Adenosine
Research Papers that Mention the Interaction
“ Adenosine , deoxyadenosine, inosine, and deoxyinosine completely prevented the toxic action of the purinethiol , while guanosine and deoxyguanosine were only partially effective.”
Enhancement of the differentiation-inducing properties of 6-thioguanine by hypoxanthine and its nucleosides in HL-60 promyelocytic leukemia cells.“As antimetabolites and closely related molecules, azathiopurine and 6-mercaptopurine inhibit adenylic and guanylic acid production in the de novo purine synthesis pathway.”
“ 6-MP inhibitory effects on the MLR were reversed by AIC (46%), adenine (32%), hypoxanthine (89%), adenosine (86%) and inosine (93%).”
“Reversal of 6-MP suppression of the MLR was decreased with the delay of adenosine addition.”
“The selective protection of the normal cells from 6-thioguanine and 6-mercaptopurine was probably the consequence of phosphoribosylpyrophosphate (PRPP) depletion, since adenosine pretreatment decreased PRPP pools by greater than 90% in the normal cells but by only 30% in the malignant hepatoma cells.”
Biochemical approaches to enhancement of antitumor drug selectivity: selective protection of cells from 6-thioguanine and 6-mercaptopurine by adenosine.“ Adenosine , and to a lesser extent guanosine, each at final concentration of 100μg/ml significantly reduced inhibition of sclerotia formation by SR in presence of 50μg/ml MP.”
6-Methylpurine-induced inhibition of sclerotia morphogenesis in Sclerotium rolfsii and its reversal by adenosine“The incorporation of adenine and of adenylic acid are affected in different ways by 6-mercaptopurine.”
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