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Last Updated: 2 years ago

Possible Interaction: Mepivacaine and Calcium Supplement

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drug:

Mepivacaine

supplement:

Calcium Supplement

Research Papers that Mention the Interaction

“High concentrations of mepivacaine appear to interfere with the transmembrane influx of calcium in the vascular smooth muscle.”

Effects of Mepivacaine on Adrenergic Neuroeffector Junction of the Isolated Rabbit Aorta

Anesthesia and analgesia • 1982 | View Paper

“Following im administration, all of the agents tested which are capable of increasing the intracellular concentration of free calcium— mepivacaine-HCl , quinidine gluconate, A23187, caffeine, and 2,4-dinitrophenol-produced extensive and qualitatively similar myonecrosis.”

Pharmacologic correlation between local anesthetic-induced myotoxicity and disturbances of intracellular calcium distribution.

Toxicology and applied pharmacology • 1980 | View Paper

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