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Discover Supplement-Drug Interactions

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Last Updated: 4 months ago

Possible Interaction: Menthol and Calcium Supplement

Research Papers that Mention the Interaction

With the use of small interfering RNA to silence the expression of TRPM8, we found that menthol could increase the concentration of intracellular calcium and decrease cell viability via the TRPM8 channel in T24 cells.
Oncology  •  2009  |  View Paper
The principal pharmacodynamic effect of peppermint oil relevant to the gastrointestinal tract is a dose-related antispasmodic effect on the smooth musculature due to the interference of menthol with the movement of calcium across the cell membrane.
Phytomedicine : international journal of phytotherapy and phytopharmacology  •  2005  |  View Paper
In summary, these findings strongly support the involvement of calcium in the penetration-enhancing effect of menthol.
Journal of pharmaceutical sciences  •  2017  |  View Paper
The latter mechanism at least in part is mediated by the SR-resident TRPM8 channel, which by activation of menthol leads to the enhancement of passive leak of Ca2+ from the SR and reduction in the amount of the releasable calcium during activation of contractions.
Fiziolohichnyi zhurnal  •  2009  |  View Paper
Menthol (10(-3) M) increased cytosolic levels of free calcium ([Ca2+]i) from 98 +/- 12 to 340 +/- 49 nM (P < 0.01) in fura-2-loaded tracheal epithelium but did not affect the intracellular adenosine 3',5'-cyclic monophosphate content.
British journal of pharmacology  •  1994  |  View Paper
Instead the results indicate a modulating action of menthol on Ca inactivation.
Neuroscience Letters  •  1986  |  View Paper