Possible Interaction: Menotropins and Progesterone

“ Progesterone concentrations on the day of human chorionic gonadotrophin (HCG) administration were significantly higher in HMG (1.5 +/- 0.9 ng/ml) versus GnRHa/HMG (0.8 +/- 0.6 ng/ml; P < 0.05) cycles.”

“CONCLUSION Lu eal su pport with P increases the PR after hMG an d hCG induction.”

“No significant increase was found in the follicular diameter of the tertiary follicles from androgen-sterilized mice as a result of stimulation by hMG, but an hMG dose of >10 mIU/mL produced a significant increase in progesterone secretion.”

“ Progesterone concentrations rose significantly faster and the oestradiol drop was more rapid after oestrus in heifers treated with hMG than in those treated with PMSG.”

“Compared to progesterone alone, HMG + progesterone led to a lower, although not significant, frequency of losses (3.3% vs. 11.9%, p = .09) and a twofold higher rate of ongoing pregnancies (41.7% vs. 19.3%, p = .002).”

“ Luteal plasma progesterone concentrations were much higher in the HMG treatment cycle.”

“We have previously shown that prophylactic supplementation of progesterone beginning in the luteal phase of patients treated with human menopausal gonadotropins ( hMG ) could reduce the risk of spontaneous abortions.”

“ Progesterone , in the absence of LDL, stimulated HMG CoA reductase activity in some of these cell lines.”

“The mechanism by which progesterone stimulates HMG CoA reductase activity is not clear, but since progesterone receptors were not detectable in these cells a mechanism independent of the classic hormone receptor-mediated phenomenon is likely to be involved.”

“Plasma estradiol and progesterone rose significantly between 24-72 hours following hMG injection.”

“The hMG treatment for 4 days raised the serum estradiol and progesterone levels to 9 times and twice those of the controls, respectively, without changing ovarian receptor levels.”