Possible Interaction: Memantine and Vitamin E

“No formal comparison of the primary outcome was reported between the group assigned to alpha … of alpha tocopherol and memantine; the statement in the “Discussion” that “… the combination of alpha tocopherol … memantine had less effect than either alpha tocopherol alone or … absence of such a comparison with significance testing.”

“The negative interaction between alpha tocopherol treatment, which was significantly beneficial alone, and memantine treatment in predicting the primary trial outcome is of concern and deserves further investigation.”