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Last Updated: 5 months ago

Possible Interaction: Memantine and Vitamin D

supplement:

Vitamin D

Research Papers that Mention the Interaction

The neuroprotective effects of memantine and vitamin D may potentiate each other, with benefits for cognition.
The Journal of Steroid Biochemistry and Molecular Biology  •  2018  |  View Paper
At 6 … taking memantine … vitamin D increased their MMSE score by 4.0 ± 3.7 points (P = 0.034), while participants taking memantine alone remained stable (change of … ± 1.8 points; P = 0.891), as did those taking vitamin D alone (-0.6 ± 3.1 points; P = 0.504).
Mixed regression analysis showed that the visit by combined treatments memantine plus vitamin D ) interaction was significant (P = 0.001), while memantine or vitamin D alone showed no effect.
Mixed regression analysis showed that the visit by combined treatments memantine plus vitamin D ) interaction was significant (P = 0.001), while memantine or vitamin D alone showed no effect.
Treatment with memantine plus vitamin D was associated with improvement in the MMSE score compared to memantine or vitamin D alone after adjustment for covariables (P < 0.01).
We prescribed memantine alone (n = 18), vitamin D alone (n = 17), or memantine plus vitamin D (n = 8) for an average of 6 months.
Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology  •  2012  |  View Paper
DiscussionThe combination of memantine plus vitamin D may represent a new multi-target therapeutic class for the treatment of ADRD.
We hypothesized that the combination of memantine with vitamin D could be neuroprotective in ADRD, thereby limiting neuronal loss and cognitive decline.
Trials  •  2011  |  View Paper
The combination of memantine plus vitamin D may provide, in one treatment, enhanced protection against several degenerative processes linked to AD.
Drugs & Aging  •  2012  |  View Paper
The combination of memantine with vitamin D , a neurosteroid hormone, may prevent blood neurotoxicity.
We provide the first evidence that cortical axons in contact with lysed blood degenerate less after exposure to lysed blood … compared to control medium and cultures enriched with only memantine or only vitamin D. The reported synergistic neuroprotective effect of memantine + vitamin D , the combination originating … following intracranial hemorrhage.
ACS chemical neuroscience  •  2015  |  View Paper
Recently, its has been proposed that the combination of memantine with vitamin D , a neurosteroid hormone, may prevent amyloid-beta and glutamate neurotoxicity.
This finding reinforces the pharmacological potential of a new drug combining memantine plus vitamin D for the treatment or the prevention of Alzheimer's disease.
We provide the first evidence that cortical axons degenerate less after exposure to amyloid-beta peptide or … medium and cultures enriched with only memantine or only vitamin D. The reported synergistic neuroprotective effect of memantine … vitamin D -the combination originating an effect stronger … this drug combination have improved cognition.
Neurobiology of Aging  •  2014  |  View Paper