Possible Interaction: Memantine and Vitamin D

“As such, vitamin D enhances the efficacy of memantine in terms of neuronal protection and prevention of cognitive decline in Alzheimer's disease.”

“The combination of memantine plus vitamin D may provide, in one treatment, enhanced protection against several degenerative processes linked to AD.”

“The neuroprotective effects of memantine and vitamin D may potentiate each other, with benefits for cognition.”

“At 6 … taking memantine … vitamin D increased their MMSE score by 4.0±3.7 points (P=0.034), while participants taking memantine alone remained stable (change of …±1.8 points; P=0.891), as did those taking vitamin D alone (−0.6±3.1 points; P=0.504).”

“Conclusions:Patients with AD who took memantine plus vitamin D for 6 months had a statistically and clinically relevant gain in cognition, underlining possible synergistic and potentiating benefits of the combination.”

“Mixed regression analysis showed that the visit by combined treatments memantine plus vitamin D ) interaction was significant (P=0.001), while memantine or vitamin D alone showed no effect.”

“Treatment with memantine plus vitamin D was associated with improvement in the MMSE score compared to memantine or vitamin D alone after adjustment for covariables (P<0.01).”

“We prescribed memantine alone (n=18), vitamin D alone (n=17), or memantine plus vitamin D (n=8) for an average of 6 months.”

“DiscussionThe combination of memantine plus vitamin D may represent a new multi-target therapeutic class for the treatment of ADRD.”

“We hypothesized that the combination of memantine with vitamin D could be neuroprotective in ADRD, thereby limiting neuronal loss and cognitive decline.”

“ Memantine with vitamin D supplementation can protect cortical axons against amyloid-β exposure and glutamate toxicity.”

“The combination of memantine with vitamin D , a neurosteroid hormone, may prevent blood neurotoxicity.”

“We provide the first evidence that cortical axons in contact with lysed blood degenerate less after exposure to lysed blood … compared to control medium and cultures enriched with only memantine or only vitamin D. The reported synergistic neuroprotective effect of memantine + vitamin D , the combination originating … following intracranial hemorrhage.”

“Recently, its has been proposed that the combination of memantine with vitamin D , a neurosteroid hormone, may prevent amyloid-beta and glutamate neurotoxicity.”

“This finding reinforces the pharmacological potential of a new drug combining memantine plus vitamin D for the treatment or the prevention of Alzheimer's disease.”

“We provide the first evidence that cortical axons degenerate less after exposure to amyloid-beta peptide or … medium and cultures enriched with only memantine or only vitamin D. The reported synergistic neuroprotective effect of memantine … vitamin D -the combination originating an effect stronger … this drug combination have improved cognition.”