Possible Interaction: Memantine and Polyphenols

“Combined treatment with memantine and tea polyphenol could significantly protect mice against excitotoxic injury by reducing the increased synaptosomal ROS production, attenuating the decreased Na+, K+‐ATPase and Mg2+‐ATPase activity, the mitochondrial membrane potential (ΔΨm), the mitochondrial reductase activity, and the increased synaptosomal Ca2+concentration.”

“Therefore, the combined treatment of memantine and tea polyphenol is more effective in neuroprotection than either memantine or tea polyphenol alone in mouse excitotoxic injury.”