Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Memantine and Polyphenols

supplement:

Polyphenols

Research Papers that Mention the Interaction

Combined treatment with memantine and tea polyphenol could significantly protect mice against excitotoxic injury by reducing the increased synaptosomal ROS production, attenuating the decreased Na+, K+‐ATPase and Mg2+‐ATPase activity, the mitochondrial membrane potential (ΔΨm), the mitochondrial reductase activity, and the increased synaptosomal Ca2+concentration.
Therefore, the combined treatment of memantine and tea polyphenol is more effective in neuroprotection than either memantine or tea polyphenol alone in mouse excitotoxic injury.
Journal of neuroscience research  •  2008  |  View Paper