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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Memantine
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“ Memantine , a current treatment used in AD, exerts some of its beneficial effects by blocking calcium entry into neurons.”
Calcium channel blockers and Alzheimer's disease: potential relevance in treatment strategies of metabolic syndrome.“However, memantine pre-treatment dose-dependently antagonized MeHg-induced neuronal toxic effects, apoptosis, Ca2+ dyshomeostasis, NMDARs expression alteration, and oxidative stress.”
Memantine, a Low-Affinity NMDA Receptor Antagonist, Protects against Methylmercury-Induced Cytotoxicity of Rat Primary Cultured Cortical Neurons, Involvement of Ca2+ Dyshomeostasis Antagonism, and Indirect Antioxidation Effects“ Memantine and the anti-NR1 antibody also attenuated a rapid ADDL-induced increase in intraneuronal calcium , which was essential for stimulated ROS formation.”
“In conclusion, TRPA1, TRPM2 and TRPV1 channels are involved in Aβ and Hcy-induced neuronal death, and modulation of the activity of these channels by MEM treatment may account for their neuroprotective activity against apoptosis, excessive ROS production, and Ca2+ entry.”
Effects of homocysteine and memantine on oxidative stress related TRP cation channels in in-vitro model of Alzheimer’s disease
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