“DMXAA increased the activity of MEL against the MDAH-MCa-4 mouse mammary tumour maximally when MEL was given about 2 h after DMXAA , without compromising the maximal dose of the alkylating agent that could be given.”
“Thus, This study was supported by the National Cancer …-47019), and the Health Research Council of New Zealand DMXAA appears … of MEL through two different mechanisms, increased exposure (via decreased tumour clearance of MEL) and increased … the tumour microenvironment, both of which result from inhibition of tumour blood flow.”