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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Melphalan and Tretinoin

supplement:

Tretinoin

Research Papers that Mention the Interaction

ATRA treatment induced upregulation of Ape/Ref-1 via a noncanonical signaling pathway, leading to enhanced pro-survival activity counteracting melphalan (an alkylating agent).
PloS one  •  2014  |  View Paper
Prior incubation with ATRA also results in increased cytotoxicity, although to a lesser degree, of phenylketophosphamide and melphalan , neither of which is a substrate for ALDHs.
Journal of Pharmacology and Experimental Therapeutics  •  2005  |  View Paper