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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Melphalan
supplement:
Phenylalanine
Research Papers that Mention the Interaction
“The uptake of melphalan was inhibited by the addition of L-phenylalanine , indicating that melphalan is incorporated through the L-phenylalanine transporter as reported previously.”
Down-Regulation of CD98 in Melphalan-Resistant Myeloma Cells with Reduced Drug Uptake“In C-6 gliomas (Ki = 0.77 +/- 0.20 mM) and contralateral control brain (Ki = 0.84 +/- 0.29 mM), melphalan also inhibited BBB phenylalanine transport.”
“The ability of melphalan to inhibit phenylalanine uptake was compared in rats implanted with two experimental CNS tumors: the C-6 glioma (a model of primary brain tumors) and Walker carcinoma (a model of metastatic brain tumors).”
Melphalan penetration of the blood-brain barrier via the neutral amino acid transporter in tumor-bearing brain.
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