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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Melphalan and Niacin



Research Papers that Mention the Interaction

A large single dose of nicotinamide (1000 mg kg-1) enhanced the tumour cell killing by L-PAM as measured by tumour cell survival.
This enhancement was maximum when nicotinamide was administered within 1 h before injecting the L-PAM.
When given at this time, the nicotinamide had a dose-modifying effect on all L-PAM doses tested, giving rise to a mean enhancement ratio (ER) of 2.2.
British Journal of Cancer  •  1986  |  View Paper
In vivo enhancement of the tumoricidal effects of L-PAM was observed with the ADPRP inhibitor nicotinamide (1000 mg/kg), although enhanced myelosuppression was also demonstrated.
Nicotinamide also increased the plasma elimination half-life of L-PAM by a factor of at least 2.
International journal of radiation oncology, biology, physics  •  1984  |  View Paper