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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“The non- benzodiazepine-type hypnotics are mostly free of chronobiotic effects, although zaleplon may increase melatonin release.”
[Sleep-modulation and hypnotics: effects of benzodiazepine-receptor's agonists].“Zaleplon compared to placebo increased significantly the melatonin levels at 23:00, 24:00 and 01:00 h. No … melatonin levels between placebo and zaleplon were found at 12:00, 22:00 and 02:00 h. Zaleplon compared to placebo increased by 46% … Area Under the Curve of melatonin ….”
“These results of the present studies suggest that zaleplon may promote melatonin secretion and the elevation of plasma levels of melatonin may suggest an influence of zaleplon on chronobiology.”
“ Zaleplon increased a dose-dependent concentration of melatonin in rabbit plasma collected at 30 min after intravenous administration at doses of 1 and 2 mg/kg.”
Effect of zaleplon, a non-benzodiazepine hypnotic, on melatonin secretion in rabbits.
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