Possible Interaction: Melatonin and Vitamin E

“Apoptosis was significantly lower after host treatment with melatonin and graft incubation with HA-rich biological glue plus VEGF-A and vitamin E than in untreated grafts; apoptosis was specifically low in Group G. There were significantly more atretic follicles in the untreated group than in most treated groups.”

“Adding α-tocopherol and MLT individually and in combination indicated a mitigative effect by reducing the genotoxic potential of treated cultures.”

“Moreover, melatonin clearly slowed radio‐induced apolipoprotein B carbonylation and protected α‐tocopherol and β‐carotene in LDL.”

“While the interaction of melatonin with ascorbate indicated synergism, the joint action of melatonin and α‐tocopherol was additive.”

“Furthermore, melatonin has been described as performing an antiaggregating activity, and ACTH and vitamin E have been described as increasing melatonin effects.”

“The oxidative stress was expressed as vitamin E consumption in the presence of melatonin or N-acetylserotonin (concentration ranging from 0.3 to 400 microM): incubation with melatonin not only lacked any protective effect but it induced a dose-dependent extra vitamin E consumption with both CHP and H2O2.”

“Concomitant use of melatonin and vitamin E could be effective on prevention of toxicity.”

“Vitamin A and E concentrations decreased in exposure group, and melatonin prevented the decrease in vitamin E levels.”

“Furthermore, the concentration of glutathione (GSH), the major brain non-enzymatic antioxidant defense, was significantly decreased by Prist and this decrease was fully prevented by melatonin and attenuated by α-tocopherol.”

“LPO levels were lower both in the two treatment groups than in the diabetic pregnant rats, whereas selenium vitamin E combination and melatonin caused a significant increase in the activities of these antioxidant enzymes (p < 0.01).”