Possible Interaction: Melatonin and Vitamin D

“Although the functions and synthesis of vitamin D and melatonin are contrary to each other, both are involved in the immune system.”

“ Vitamin D and melatonin could be good options for achieving this aim, taking into account that they have many shared underlying mechanisms that are able to modulate and control the immune adequately and oxidative response against COVID-19 infection, possibly even through a synergistic interaction.”

“ Vitamin D is also involved in the pathways of production of Melatonin , the hormone involved in the regulation of human circadian rhythms and sleep.”

“In this regard, we have previously shown that melatonin in combination with vitamin D , is able to counteract the appearance of an adipogenic phenotype in adipose derived stem cells (ADSCs), cultured in an adipogenic favoring condition.”

“The transcription of specific adipogenesis orchestrating genes, such as aP2, peroxisome proliferator-activated receptor γ (PPAR-γ), and that of adipocyte-specific … lipoprotein lipase (LPL) and acyl-CoA thioesterase 2 (ACOT2), was significantly inhibited in cells that had been treated in the presence of melatonin … vitamin D , alone … combination.”

“Notably, in an additional study, we found that some effects attributed to vitamin D may be related to another lightdependent factor: melatonin.”

“We didn't evaluate simultaneous level of 25-OH Vitamin D. It has been recently reported that there is a negative correlation between melatonin and vitamin D levels.”

“We hypothesized that vitamin D and melatonin may have related influences in patients with MS.”

“Abstract: Melatonin and vitamin D3 inhibit breast cancer cell growth and induce apoptosis, but they have never been combined as a breast cancer treatment.”

“Concomitantly, melatonin and D3 , alone or in combination, caused a significant reduction in Akt phosphorylation and MDM2 values, with a consequent increase of p53/MDM2 ratio.”

“In MCF‐7 breast cancer cells, melatonin together with vitamin D3 , induced a synergistic proliferative inhibition, with an almost complete cell growth arrest at 144 hr.”

“The tryptophan-enriched diet D3 ) showed 5.8-fold higher melatonin and 4.4-fold lower cortisol levels in rohu compared to the D5FL treatment.”