Possible Interaction: Melatonin and Vitamin C

“Patients requested less supplemental analgesic and experienced less nausea and vomiting in groups … compared with group P. In conclusion, preoperative oral administration of 6 mg melatonin … vitamin C led to a reduction in pain scores, total morphine consumption, supplemental …, and the incidence of nausea and vomiting compared with placebo.”

“ Melatonin reduced the levels of ascorbic acid (P < .05) but not dehydroascorbic acid or malondialdehyde.”

“In this study, we showed that melatonin synergizes with vitamin C to derail exit from pluripotency of mouse ESCs.”

“Administration of a single dose of melatonin (10 mg/kg body weight) and ascorbic acid (10 mg/kg body weight) intraperitoneally for three consecutive days decreases the carbonyl content in 1- and 18-month-old mice significantly.”

“ Melatonin reduced, in a concentration-dependent manner, lipid and protein oxidation due to Al, FeCl(3) and ascorbic acid in the synaptosomal membranes.”

“ Melatonin co‐infusion restored SIN‐1 effects on dialysate DA and antagonized SIN‐1‐induced ascorbic acid decreases.”

“Moreover, melatonin increased dialysate recovery of ascorbic acid released from PC12 cells.”

“A combination of MEL + NMMA completely blocked both AA and LHRH release, supporting a role for NO in the releasing action.”

“ Melatonin (10−6 and 105 M) significantly stimulated both AA and LHRH release, but the lower and the highest concentrations were ineffective.”

“ Melatonin attenuated the … hepatic ASC concentrations and SOD, CAT and GSSG‐R activities and the increase in hepatic XO activity in a dose‐dependent manner without affecting … hepatic Se‐GSH‐Px activity or the increased hepatic VE concentration and G‐6‐PDH activity at 24 hr after CCl4 treatment.”

“These results indicate that melatonin postadministered at pharmacological doses prevents the disruption of hepatic ROS metabolism associated with ASC , SOD, CAT, GSSG‐R, and XO, in addition to reduced glutathione, in CCl4‐treated rats.”

“At the neuroprotective dose, melatonin treatment was associated with sustained (4 days) elevation of brain LMWA, including ascorbic acid (P<0.05).”

“The thicknesses of the retina and inner plexiform layer in group EU plus vitamin C , group EU plus aprotinin and group EU plus melatonin were significantly (p < 0.01) lower than that in the group EU.”