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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Melatonin
drug:
Vinorelbine
Research Papers that Mention the Interaction
“Docetaxel and vinorelbine increased the expression of VEGF-A , VEGF-B , VEGF-C , VEGFR-1 , VEGFR-3 , ANG1 and/or ANG-2 and melatonin inhibited these actions.”
“Our results confirm that melatonin blocks proangiogenic and potentiates antiangiogenic effects induced by docetaxel and vinorelbine enhancing their antitumor effectiveness.”
“Regarding to estrogen biosynthesis, melatonin impeded the negative effect of vinorelbine , by decreasing the activity and expression of aromatase and sulfatase.”
“…,melatonin prevented the positive actions that docetaxel exerts on the expression of other factors related to angiogenesis like … , ANPEP , IGF-1 , CXCL6 , AKT1 , ERK1 , ERK2 , MMP14 and NOS3 and neutralized the stimulating actions of vinorelbine on the expression of FIGF , FGFR3 , CXCL6 , CCL2 , ERK1 , ERK2 , AKT1 , NOS3 and MMP14 .”
Usefulness of melatonin as complementary to chemotherapeutic agents at different stages of the angiogenic process“ Melatonin potentiates the stimulatory effect of docetaxel and vinorelbine on differentiation and their inhibitory effects on aromatase activity and expression, by increasing the stimulatory effect on C/EBPα and PPARγ expression and the downregulation of antiadipogenic cytokines and COX expression.”
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