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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Melatonin
drug:
Vincristine
Research Papers that Mention the Interaction
“Here, we found that there is a synergy in the antitumor effect when melatonin (50 μm–1 mm) is combined with vincristine at the concentration of 5–10 nm or with ifosfamide at the range of 100 μm–1 mm.”
“There is a significant increase in the activation of caspase‐3, ‐8, ‐9 and Bid when melatonin is combined with vincristine or ifosfamide compared to the individual treatments.”
Synergistic antitumor effect of melatonin with several chemotherapeutic drugs on human Ewing sarcoma cancer cells: potentiation of the extrinsic apoptotic pathway“HCT-116 in-vitro test proved the strong cytotoxic effect of VCR and Melatonin synergism on the apoptosis level (Caspases 3 and 9 increased levels) and inhibitory concentration 50%.”
Study of the possible synergistic protective effects of Melatonin and Pregabalin in Vincristine induced peripheral neuropathy Wistar Albino rats.
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