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Last Updated: 3 years ago

Possible Interaction: Melatonin and Verapamil

supplement:

Melatonin

Research Papers that Mention the Interaction

These findings imply that verapamil influences the renal and/or hepatic handling of melatonin.
Verapamil did not affect nocturnal melatonin secretion but increased melatonin excretion by 145%.
European journal of clinical investigation  •  1997  |  View Paper
In the absence of endothelium, verapamil but not nifedipine further inhibited the melatonin relaxation.
Nifedipine and verapamil partly inhibited the melatonin relaxation on the 5-HT response.
General pharmacology  •  1991  |  View Paper
Both no calcium-EDTA medium and verapamil (10(-5) M) prevented the stimulation of GnRH release by 60 mM potassium, 10(-3) M melatonin , and 4 X 10(-4) M prostaglandin E2.
Endocrinology  •  1978  |  View Paper
Melatonin (10-7 M) potentiated the relaxation response of the strips by verapamil , but other potassium channel blockers did not change melatonin activity.
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology  •  2012  |  View Paper