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“These findings suggest that by affecting the vasoconstrictor system, melatonin has a causal role in the nocturnal changes in body temperature and its control.”
“These results support the hypothesis that melatonin , by inhibiting the action of nitric oxide on coronary vascular smooth muscle, selectively potentiates the vasoconstrictor response to serotonin in coronary arteries with endothelium.”
American journal of physiology. Heart and circulatory physiology • 2001 | View Paper
“It is proposed that the requirement of preactivation for overt vasoconstrictor responses to melatonin results from the low effector reserve of the melatonin receptors together with the tail artery having threshold inertia.”
“Potentiative interactions between melatonin and other vasoconstrictor stimuli probably also result from the threshold inertia.”