Possible Interaction: Melatonin and Tretinoin

“Combined treatment with melatonin and retinoic acid decreased the expression of the Bcl-2.”

“The combined effect of retinoic acid and melatonin decreased the activity of the electron transport chain complexes.”

“Taken together our results indicate that co-administration of melatonin with all-trans retinoic acid and somatostatin may be of significant therapeutic benefit in breast cancer.”

“In contrast, melatonin potentiates the action of all‐trans‐retinoic acid on RARα transcriptional activation and enhances RARα/DNA binding activity, an action which is not PTX‐sensitive.”

“Our laboratory has previously demonstrated that Mlt and all-trans-retinoic acid (atRA) not only inhibit the proliferation, but also induce apoptosis of MCF-7 cells when used in a sequential regimen of Mlt followed 24 h later by atRA.”

“These data suggest that the sequential treatment regimen of Mlt and atRA may induce apoptosis by modulation of members of the Bcl-2 family of proteins.”

“ Tretinoin added to the culture caused a statistically significant reduction in [3H]thymidine incorporation into the cancer cells, compared to the melatonin … groups, when treatment with retinoid was synergistic (39.05% +/- 5.44, p < 0.05) or sequential (tretinoin and after 24 h melatonin ) (39.96% +/- 1.… < 0.05).”

“One micromolar melatonin induced the expression of gamma-GCS mRNA followed by an increase in … GSH with a peak at 24 h. An electrophoretic mobility shift assay showed that melatonin stimulates the DNA-binding activity of … (AP-1) as well as retinoid Z receptor/retinoid receptor-… alpha (RZR/RORalpha).”

“In vitro, RA promoted osteoclasts and inhibit osteogenesis by increasing oxidative stress levels in the RAW264.7 and MC3T3-E1 cells, but melatonin reversed this effect.”

“ Melatonin treatment alleviated these effects induced by RA , increasing the amount of trabecular bone in OP mice, improving the microstructure of the femur and vertebra(L1) and increasing bone mass bone density and the expression of ALP, as well as decreasing the number of osteoclasts.”

“Melatonin is required for normal corneal growth in vivo, and together melatonin and RA , or RA alone, affects the regulation of water content within the chick cornea.”

“We found that, during CL exposure, combined application of melatonin and RA eye drops increased the depth of the anterior segment in vivo, (P = 0.003) and interestingly, both also reduced the hyperopia of CL exposure after 2 weeks (P = 0.002), thus partially reversing the effects of CL.”

“The results of all these evaluations demonstrated that the dual delivery of Mel and TTN could accumulate a safety (without high-dose toxicity) synergistic anti-oxidative effect in oocyte/embryo by passive controlled, and inhibit intra/extracellular ROS levels by an enhanced intracellular penetration.”

“Serotonin, 9-cis retinoic acid, all-trans retinoic acid , flavin mononucleotide in muscles were downregulated after melatonin administration.”