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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Melatonin and Tranylcypromine

supplement:

Melatonin

Research Papers that Mention the Interaction

In humans, both the MAO-A selective inhibitor clorgyline and the non-selective inhibitor tranylcypromine increase serum melatonin levels.
Drug metabolism and drug interactions  •  1990  |  View Paper
ABSTRACT— Strong negative correlation has been observed between nighttime (physiological) elevation of plasma melatonin and plasma melatonin increase induced by a single dose of MAO inhibitor, tranylcypromine.
Acta psychiatrica Scandinavica  •  1988  |  View Paper
Tranylcypromine , a nonselective MAO inhibitor given in doses of 20-40 mg/day for 3 weeks, significantly elevated plasma melatonin to 10.6 +/- SD 2.0 pg/ml.
Psychiatry Research  •  1986  |  View Paper
Two commonly used monoamine oxidase inhibitors, tranylcypromine and pargyline, produced dose-dependent decreases in the activity of serotonin-containing neurons in the dorsal raphe in awake, freely-moving cats.
Neuropharmacology  •  1985  |  View Paper
Tranylcypromine , a monoamine oxidase inhibitor which preserves serotonin and eventually increases the level of melatonin in tissues, facilitated IOP recovery.
Ophthalmic research  •  1984  |  View Paper