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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Melatonin
drug:
Tranylcypromine
Research Papers that Mention the Interaction
“In humans, both the MAO-A selective inhibitor clorgyline and the non-selective inhibitor tranylcypromine increase serum melatonin levels.”
Neuropharmacology of pineal secretions.“ABSTRACT— Strong negative correlation has been observed between nighttime (physiological) elevation of plasma melatonin and plasma melatonin increase induced by a single dose of MAO inhibitor, tranylcypromine.”
“ Tranylcypromine , a nonselective MAO inhibitor given in doses of 20-40 mg/day for 3 weeks, significantly elevated plasma melatonin to 10.6 +/- SD 2.0 pg/ml.”
“Two commonly used monoamine oxidase inhibitors, tranylcypromine and pargyline, produced dose-dependent decreases in the activity of serotonin-containing neurons in the dorsal raphe in awake, freely-moving cats.”
Unit activity in the dorsal raphe in freely-moving cats Effects of monoamine oxidase inhibitors“ Tranylcypromine , a monoamine oxidase inhibitor which preserves serotonin and eventually increases the level of melatonin in tissues, facilitated IOP recovery.”
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