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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“In in vitro study of the human euthyroid and thyrotoxic thyroid gland melatonin (N-acetyl-5-methoxytryptamine) and, to a lesser measure mexamine (5-methoxytryptamine) had a dose-dependent inhibiting effect on thyroxine secretion.”
[The effect of melatonin and mexamine on the human thyroid under in-vitro conditions].“Melatonin is a hormone known to modulate the estrous cycle and pregnancy, and studies show that the exogenous application of melatonin increased T4 levels in female rats and controlled the decrease in T3 serum levels, reverting the sigs of hypothyroidism.”
Melatonin on hypothyroidism and gonadal development in rats: a review“Concentration of FSH, LH, testosterone and MT were higher and concentration of T4 , cortisol and prolactin were lower in MT treated than in untreated control group.”
“These results indicate that treatment with L-thyroxine increases stimulated and non-stimulated AVP release that are inhibited by melatonin supplementation.”
“In vitro l-thyroxine (10(-6)M/ml) supplementation decreased the splenocyte proliferation which was reversed by melatonin (500 pg/ml) supplementation.”
“Interaction of thyroxine and melatonin on immune status was noted in vivo and in vitro when peripheral melatonin was high and thyroxine low in plasma of male Perdicula asiatica during reproductively inactive phase.”
“Thus, the modulation of DA release could be one mechanism by which melatonin interacts with hormones, like prolactin and thyroxine that are involved in the regulation of anuran development and metamorphosis.”
“Exogenous melatonin administration caused delays in the acrophases of T3, T4 and melatonin rhythm itself; whereas advances in the acrophases of TSH were observed, thus indicating chronic administration of melatonin could alter the characteristics of endocrine rhythms.”
“Therefore, a trade-off effect of L-thyroxin and melatonin on the immune system (T- and B-cell differentiation) is suggested for this rodent.”
“However, 2-week exposure to T4 caused a reduction in night-time plasma melatonin level and thus, probably, inhibited melatonin related time-keeping system in juvenile salmon.”
“ Melatonin elevates the plasma leptin and thyroxine levels possibly by direct and indirect mechanisms.”
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