Possible Interaction: Melatonin and Thyrotropin-Releasing Hormone

“This paper shows that nootropic drugs like piracetam (2‐oxo 1 pyrrolidine acetamide) and levetiracetam and neuropeptides like TRH antagonise the inhibition of glucose transport by barbiturates, diazepam, melatonin and endogenous neuropeptide galanin in human erythrocytes in vitro.”

“A significant increase in melatonin levels after TRH was seen only in the prepubertal females, with a peak at 120 min.”

“PRL response to TRH was higher after MT in the follicular phase, when evaluated in terms of net increment and integrated area of response (p less than 0.02 versus baseline conditions for both variables).”

“These results show that daily exposure to MEL under a long day length reduces the PRL-releasing response to SAL as well as TRH and sulpiride in goats.”

“Hypothalamic concentrations of thyrotropin-releasing hormone (TRH) were significantly elevated by melatonin injections and by short photoperiodic conditions, but not by thiourea administration.”

“MEL decreased plasma TSH levels as compared to non-treated and saline-treated controls, whereas the concurrent administration of TRH obviated the effect of MEL and increased plasma TSH levels above those of the control animals.”