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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Melatonin
drug:
Tetrodotoxin
Research Papers that Mention the Interaction
“The inhibitory effects of the kainate-induced response by melatonin tended to increase with higher melatonin concentrations and persisted in the presence of tetrodotoxin , a voltage-sensitive Na+ channel blocker, or luzindole, a non-selective melatonin receptor antagonist.”
Melatonin Suppresses the Kainate Receptor-Mediated Excitation on Gonadotropin-Releasing Hormone Neurons in Female and Male Prepubertal Mice“Melatonin‐induced effects were blocked by the MT1/MT2 antagonist, luzindole (1 μm) and the proportion of SCN neurones responsive to melatonin was greatly reduced in the presence of either tetrodotoxin (200 or 500 nm) or gabazine (20 μm).”
“The neurotoxin tetrodotoxin blocked the inhibitory effect of melatonin on SNP-induced Isc.”
“For both targets, SCN and PVN, the application of tetrodotoxin by reverse dialysis in the middle of the night decreased melatonin levels.”
“ TTX inhibited the ability of light to increase Per1 and Per2 mRNA levels and suppress pineal melatonin levels.”
“ Melatonin inhibited phase advances by the 5-HT agonist, (+)DPAT, and this inhibition was decreased by co-application of tetrodotoxin.”
“Pretreatment of vessels with 6‐hydroxydopamine, lidocaine, or tetrodotoxin antagonized the relaxant response to melatonin.”
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