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Last Updated: 3 years ago

Possible Interaction: Melatonin and Tetrodotoxin

supplement:

Melatonin

Research Papers that Mention the Interaction

The inhibitory effects of the kainate-induced response by melatonin tended to increase with higher melatonin concentrations and persisted in the presence of tetrodotoxin , a voltage-sensitive Na+ channel blocker, or luzindole, a non-selective melatonin receptor antagonist.
International journal of molecular sciences  •  2020  |  View Paper
Melatonin‐induced effects were blocked by the MT1/MT2 antagonist, luzindole (1 μm) and the proportion of SCN neurones responsive to melatonin was greatly reduced in the presence of either tetrodotoxin (200 or 500 nm) or gabazine (20 μm).
Journal of neuroendocrinology  •  2010  |  View Paper
The neurotoxin tetrodotoxin blocked the inhibitory effect of melatonin on SNP-induced Isc.
European journal of pharmacology  •  2008  |  View Paper
For both targets, SCN and PVN, the application of tetrodotoxin by reverse dialysis in the middle of the night decreased melatonin levels.
The European journal of neuroscience  •  2004  |  View Paper
TTX inhibited the ability of light to increase Per1 and Per2 mRNA levels and suppress pineal melatonin levels.
The European journal of neuroscience  •  2004  |  View Paper
Melatonin inhibited phase advances by the 5-HT agonist, (+)DPAT, and this inhibition was decreased by co-application of tetrodotoxin.
Brain Research  •  1999  |  View Paper
Pretreatment of vessels with 6‐hydroxydopamine, lidocaine, or tetrodotoxin antagonized the relaxant response to melatonin.
Journal of pineal research  •  1995  |  View Paper