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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Melatonin
drug:
Tetraethylammonium
Research Papers that Mention the Interaction
“However, binding of tetraethylammonium to its receptor decreases the melatonin affinity, and vice versa.”
Multiple binding sites for melatonin on Kv1.3.“Electrophysiologically, application of melatonin selectively inhibited the tetraethylammonium (TEA)-sensitive K+ current component, but did not show any effect on the 4-aminopyridine (4-AP)-sensitive component.”
Melatonin inhibits tetraethylammonium-sensitive potassium channels of rod ON type bipolar cells via MT2 receptors in rat retina“This … of melatonin was partially blocked in the presence of apamin (10(-10) to 10(-7) M), a specific blocker of the small conductance calcium-… channel, but not in the presence of other potassium channel blockers like charybdotoxin (10(-8) M), glibenclamide (l0(-5) M), or tetraethylammonium (ODQ, …) M).”
“Furthermore, addition of a blocker of Ca2+‐activated K+ channels, tetraethylammonium (1 mM), significantly attenuated potentiating effects of melatonin.”
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