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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Melatonin
drug:
Temozolomide
Research Papers that Mention the Interaction
“Moreover, melatonin delayed cell cycle progression and potentiated the reduction of cell survival due to treatment with the chemotherapeutic agent temozolomide.”
Mitochondria Transcription Factor A: A Putative Target for the Effect of Melatonin on U87MG Malignant Glioma Cell Line“The Nrf2 inhibitors VPA and MEL successfully reduced Nrf2 expression and survival in U251‑TMZ cells treated with TMZ , accompanied by increased reactive oxygen species levels and apoptosis.”
“Results:Combinations of melatonin and chemotherapeutic drugs (including temozolomide , current treatment for malignant gliomas) have a synergistic toxic effect on BTSCs and A172 malignant glioma cells.”
“As pretreatment to TMZ, melatonin 1 mM and 50 nM significantly reduced proliferation.”
Do Anti-Oxidants Vitamin D3, Melatonin, and Alpha-Lipoic Acid Have Synergistic Effects with Temozolomide on Cultured Glioblastoma Cells?
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