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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Melatonin
drug:
Substance P
Research Papers that Mention the Interaction
“CP injection resulted in severe cystitis with increase in voiding behaviors, histological damage, mast cell proliferation, SP , and proinflammatory cytokine expression, which were significantly downregulated by melatonin pretreatment.”
“ Melatonin significantly improved bladder symptoms and histological damages in rats with CP-induced cystitis by diminishing bladder oxidative stress, blocking iNOS, upregulation of HO-1, and downregulating the expression of SP.”
Melatonin Improves Bladder Symptoms and May Ameliorate Bladder Damage via Increasing HO-1 in Rats“However, in the presence of NE, substance P inhibited the NE-induced increase in AANAT activity and melatonin secretion.”
“The present results show that the stimulatory effect of substance P on basal release of AVP and OT from rat hypothalamo-neurohypophysial system in vitro is sensitive to inhibitory influence of melatonin.”
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