Possible Interaction: Melatonin and Steroids

“The normalization of aMT6s and testosterone values during cyproterone acetate-ethinyl estradiol treatment, suggest that sex steroids either directly or through the suppression of gonadotropin, modulate melatonin secretion in these patients.”

“Moreover, RT or steroid therapy-related toxicities were lower in patients concomitantly treated with MLT.”

“A negative correlation between circulating melatonin and sex steroids has been observed in a number of instances, and appears to be independent of concomitant gonadotrophins.”

“S I. The following discussion m i l l review some recent findings that support the hypothesis that melatonin is an oncostatic hornioiw by virtue of its iibility t o inhibit the mitogenic action of steroids ;~nd polypeptide hormones and growth tictors.”

“ Melatonin interferes in sex steroid production, boosting progesterone output.”

“In addition, melatonin inhibits the secretion of gonadotropin-releasing hormone and may directly affect steroid metabolism within the ovaries and progesterone synthesis.”

“In addition, melatonin inhibits the secretion of gonadotropin-releasing hormone and may directly affect steroid metabolism within the ovaries and progesterone synthesis.”

“In fact, melatonin may influence production and action of steroids , modifying cellular signalization on the target tissue.”

“Taken together, our results suggest that both gonadotropins and gonadal steroids modulate melatonin secretion in humans.”

“The decrease in aMT6s excretion together with reduced serum LH, FSH, DHEAS and testosterone values during treatment with cyproterone acetate-ethinyl estradiol, suggest that sex steroids either directly or through the suppression of gonadotropins, modulate melatonin secretion in these patients.”