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“ Melatonin inhibited Akt activation, thus decreasing P‐GSK3B at serine 9 (i.e., increasing GSK3B activity) and subsequently inhibiting expression of Cxcl1 and Ccl20 that was induced either by IL‐17 alone or by a combination of insulin and IL‐17.”
“Electron microscopy of the testes of the rats demonstrated that pretreatment with melatonin was particularly effective in preventing mitochondrial degeneration, dilatation of SER , and enlarged intercellular spaces in both Sertoli and spermatid cells in the I/R treated animals.”
Experimental and molecular pathology • 2010 | View Paper
“Collectively, the present study reports for the first time that SER not only inhibits the independent actions of MIH , but also the actions of MEL on the MIH-induced oocytes maturation in carp.”
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology • 2008 | View Paper
“Other early apoptotic events such as plasma membrane exposure of phosphatidyl serine and the positive YOPRO‐1 staining of the early apoptotic nucleus were also prevented by melatonin.”