Possible Interaction: Melatonin and Selenium

“Conclusion Our results indicated the possibility that the supplementation of melatonin and selenium , two antioxidant agents for the treatments in the rhinosinusitis rat model, might be reduced or prevent anosmia.”

“Addition of 6 mmol of melatonin significantly reduced the rate of lipid peroxidation in sperm of unselected donors (mean +/- SE in control samples = 26.4 +/- 2.9 vs. 6.5 +/- 1.1 nmol MDA/108 sperm in melatonin-treated samples; n = 16, p <.”

“However, plasma Se levels increased significantly (P < 0.05) after melatonin supplementation in both groups (M-ZDF and M-ZL).”

“ Melatonin administration significantly enhanced plasma Se levels in both groups (M-ZDF and M-ZL).”

“This is the first study to report that melatonin treatment increases plasma Se levels.”

“LPO levels were lower both in the two treatment groups than in the diabetic pregnant rats, whereas selenium –vitamin E combination and melatonin caused a significant increase in the activities of these antioxidant enzymes (p < 0.01).”

“The synergistic scavenger effects of selenium and melatonin collectively we called Se-Mel was studied on the prevention of neuronal injury induced by ischemia/reperfusion.”

“ Melatonin application in Group 3 (1.13±0.28 μg/g tissue) and Group 4 (1.89±0.48 μg/g tissue) caused an increase in selenium levels.”

“ MT promotes the accumulation of chelating agents in the roots, detoxifies Se there, and impedes its further translocation to the leaves.”

“Relative to standalone Se treatment, the combination of MT and Se upregulated the ROS-detoxifying enzymes SOD, APX, GR, and CAT, increased proline, free amino acids, and the thiol components GSH, GSSG, GSH/GSSG, NPTs, PCs, and cys and upregulated the metabolic enzymes γ-ECS, GST, and PCS.”

“Pretreatment with different forms of Se significantly induced the biosynthesis of melatonin and its precursors (tryptophan, tryptamine, and serotonin); selenocysteine had the most marked effect on melatonin biosynthesis.”