Possible Interaction: Melatonin and Resveratrol

“The fact that melatonin and resveratrol are present in various foods, exhibiting possible synergistic effects, suggests the use of dietary ingredients to promote health and longevity.”

“In conclusion, our results suggest that the combination of resveratrol and melatonin supported a synergistic increase in oocyte nuclear maturation and total cell numbers of PA blastocysts and improved the development of SCNT embryos.”

“Conclusion: These results emphasize that coadministration of melatonin and resveratrol can be beneficial in BCCAO-induced vascular dementia through changes in BDNF expressions.”

“The combination of resveratrol and melatonin reduced tumour incidence by approximately 17% and significantly decreased the quantity of invasive and in-situ carcinomas.”

“ Melatonin + RSV showed a synergistic increase in the expression levels of HO‐1 protein but not in the HO‐1 mRNA level compared to either melatonin or RSV alone, which is mediated by the activation of PI3K‐Akt pathway.”

“These data suggest that melatonin potentiates the neuroprotective effect of RSV against oxidative injury, by enhancing HO‐1 induction through inhibiting ubiquitination‐dependent proteasome pathway, which may provide an effective means to treat neurodegenerative disorders.”

“Co-treatment with MEL and RES exerted beneficial additive effects on recognition memory impairment in the AD mouse model.”

“Results Melatonin has a lower antioxidant capacity only 5% of the capacity of resveratrol.”

“Additionally, the contents of 18 of the 22 detected individual phenolic compounds were enhanced by MT treatment; particularly, the resveratrol content was largely increased concomitantly with the up-regulation of STS gene expression.”

“It was also found that …/L) and the combination of resveratrol (2.…) plus melatonin (10−7 mol/L) exhibited more potent effects than resveratrol alone regarding their protective activities on oocyte maturation … study compared the efficiencies of resveratrol, melatonin and their combination for protecting porcine oocytes from heat stress.”

“The purpose of this investigation was to assess whether the co-administration of MEL and RSV exerts synergistic effects on their neuroprotective properties against β-amyloid (Aβ)-induced neuronal death.”