Possible Interaction: Melatonin and Recombinant Human Chorionic Gonadotropin

“ Melatonin alone had no significant effect on the amount of estrogen produced, but in combination with hCG , a significant increase in estrogen followed (P less than 0.05).”

“ Melatonin also synergized with HCG in increasing progesterone production on days 6 and 7 after treatment during both light and dark periods.”

“The addition of melatonin to the hCG-treated granulosa lutein cells significantly (P less than 0.05) potentiated the stimulatory effect of hCG on P production.”

“Melatonin (0.1–10 ng/ml) had no effect on steroid production in the absence of hCG, but melatonin decreased progesterone and estradiol production by preovulatory follicles in a dose‐dependent and time‐dependent manner in the presence of hCG (100 mlU/ml).”

“T response to human chorionic gonadotropin hCG ) was blunted by melatonin treatment at 30 days of life.”

“The influence of melatonin treatment and 35 C temperature appears to be additive for testicular weight and testosterone release after hCG.”

“The single hCG treatment caused significant reversal of the suppression of accessory sex organ weights following melatonin , short days or 35 C temperature.”

“ Melatonin alone significantly decreased the accumulation of steroids elicited by HCG stimulation.”

“Administration of the indoles 5-methoxytryptophol, 6-hydroxymelatonin, melatonin , N-acetylserotonin or 5-methoxyindole-3-acetic acid (six 100-mug injections given at intervals of 12 h) inhibited both the absolute and relative ovarian and uterine weights of immature female mice pre-treated with HCG.”

“Compared with placebo, some chemicals were found to be significantly up-regulated on HCG trigger day and 14 days after embryo transplantation, i.e., PIP3(16:0/16:1), PIP2(18:1/18:1), tauroursodeoxycholic acid, L-asparagine, L-glutamic acid, kynurenic acid, 11-deoxycorticosterone, melatonin glucuronide, hydroxytyrosol.”