Possible Interaction: Melatonin and Propofol

“Oral premedication with 0.2 mg/kg melatonin significantly reduces the propofol and thiopental doses required for loss of responses to verbal commands and eyelash stimulation.”

“The sedation, anxiety, and propofol dose used were lower in the melatonin group than the placebo group.”

“Conclusion: Melatonin premedication, in an oral dose of either 3 or 5 mg, reduced the required dose of propofol to achieve a BIS score of 45, reflecting a sufficient level of hypnosis for tracheal intubation without prolongation of postoperative recovery room stay.”

“We hypothesized that melatonin decreases the amount of propofol required to produce an adequate depth of hypnosis at induction time.”

“CONCLUSIONS Melatonin premedication significantly decreased the doses of both propofol and thiopental required to induce anesthesia.”

“Potentially, melatonin could be used to minimize the level of excitement before general anesthesia and to reduce the required propofol dose for induction.”

“Conclusions:The results demonstrate the disturbing effects of propofol anesthesia on the circadian rhythm of plasma melatonin in rats under normal light conditions.”

“Cosinor analysis suggests that propofol induces a phase advance of the circadian secretion of peripheral melatonin.”

“Induction dose of propofol (1.42 mg.kg-1 vs. 2.01 mg.kg-1) and the number of patients requiring additional fentanyl intraoperatively (3 vs. 11) were also significantly reduced in the melatonin group.”