Possible Interaction: Melatonin and Progesterone

“Since the expression of BMP-6 in granulosa cells is increased in patients with polycystic ovary syndrome, melatonin may play an important role in the maintenance of progesterone production by suppressing BMP-6 signaling, leading to the preservation of ovarian function.”

“ Melatonin treatment also improves progesterone production by corpus luteum in infertile women with luteal phase defect.”

“ Melatonin perfused through the corpus luteum at a physiological concentration, significantly stimulated progesterone secretion but the response was not as rapid as that to hCG.”

“ Melatonin significantly stimulated progesterone production by granulosa cells in vitro after two days of culture, but the degree of response depended on the size of the follicles from which the cells were obtained.”

“At high (200 pg/ml) but not low (20 pg/ml) physiological concentrations, melatonin significantly stimulated progesterone production by human granulosa cells.”

“Exposure to melatonin for 8 h significantly stimulated progesterone secretion to a level similar to that achieved under continuous exposure, and the effect was reduced to control levels during subsequent periods in which no melatonin was added.”

“ Melatonin significantly stimulated progesterone production by bovine granulosa cells in vitro, at concentrations similar to those present during the endogenous nocturnal rise (100-400 pg/ml).”

“ Melatonin may also independently stimulate granulosa cell production of progesterone.”

“These results show that, at least over a short period (90 min), melatonin is progonadal, in that it augments gonadotropic stimulation of granulosa cells and leads to increased synthesis of estrogen or progesterone.”

“ Melatonin interferes in sex steroid production, boosting progesterone output.”

“Background Melatonin stimulates the production of progesterone , which is essential for the maintenance of pregnancy.”

“In addition, melatonin inhibits the secretion of gonadotropin-releasing hormone and may directly affect steroid metabolism within the ovaries and progesterone synthesis.”

“In addition, melatonin inhibits the secretion of gonadotropin-releasing hormone and may directly affect steroid metabolism within the ovaries and progesterone synthesis.”

“ Melatonin treatment alone had no effect on basal progesterone production but enhanced the effects of human CG-stimulated progesterone production.”