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Last Updated: 2 years ago

Possible Interaction: Melatonin and Prednimustine

supplement:

Melatonin

Research Papers that Mention the Interaction

Exposure of CHO-MT(1) cells to melatonin (400 pM) for 0.5, 1, 2, 4, and 8 hr significantly increased specific 2-[125I]iodomelatonin (500 pM ) binding to hMT(1) melatonin receptors upon 16-hr withdrawal.
Biochemical pharmacology  •  2003  |  View Paper
Melatonin at concentrations of 1 nM and 10 pM (within the range of concentrations that correspond to physiological night-time and daytime levels in human blood) significantly inhibited proliferation in both melanoma cell lines.
Melanoma research  •  2001  |  View Paper
Melatonin inhibited [… 20 pM with a maximal inhibitory effect (80%) at 1 nM. The partial agonists, i.e., N-acetyltryptamine (IC50: 5.6, maximal inhibition 55%) and … 40%) showed various degrees of efficacy while none of the competitive melatonin receptor antagonists did inhibit [3H]dopamine release on their own.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  1997  |  View Paper
Melatonin also reduced the oscillatory pattern of Ca2+ mobilization evoked by a physiological concentration of CCK-8 (20 pM ), and completely inhibited Ca2+ mobilization induced by 10 pM CCK-8.
Journal of Physiology and Biochemistry  •  2013  |  View Paper
In 32% of cells, increasing melatonin concentrations in the range of 1 pM to 100 nM prolonged the latency of, and inhibited GnRH (10 nM)-stimulated [Ca2+]i increases in a concentration-dependent manner.
Neuroendocrinology  •  2001  |  View Paper
Intrahypothalamic injection of Mel (2 micrograms) enhanced CL value of PM subliminal diameter of in normal and pinealectomized rats.
The same treatment of Mel increased CL value of PM subliminal diameter of and depressed hypothalamic dinoprostone production in intact rats.
Zhongguo yao li xue bao = Acta pharmacologica Sinica  •  1995  |  View Paper
The addition of melatonin at 100 pM or 1 µM in the cocktail medium partially prevented the decrease in viability without PS translocation and the increase in capacitated spermatozoa from all breeds, with no significant effect on phosphotyrosine levels.
Animals : an open access journal from MDPI  •  2021  |  View Paper
In rings which were preincubated with melatonin at a concentration of 360 pM , a 56.5% reduction of effect size could be achieved (4.09 ± 1.22 mN versus 9.41 ± 1.74 mN, P < 0.0001).
Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society  •  2017  |  View Paper