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“Exposure of CHO-MT(1) cells to melatonin (400 pM) for 0.5, 1, 2, 4, and 8 hr significantly increased specific 2-[125I]iodomelatonin (500 pM ) binding to hMT(1) melatonin receptors upon 16-hr withdrawal.”
“ Melatonin at concentrations of 1 nM and 10 pM (within the range of concentrations that correspond to physiological night-time and daytime levels in human blood) significantly inhibited proliferation in both melanoma cell lines.”
“ Melatonin inhibited [… 20 pM with a maximal inhibitory effect (80%) at 1 nM. The partial agonists, i.e., N-acetyltryptamine (IC50: 5.6, maximal inhibition 55%) and … 40%) showed various degrees of efficacy while none of the competitive melatonin receptor antagonists did inhibit [3H]dopamine release on their own.”
Naunyn-Schmiedeberg's Archives of Pharmacology • 1997 | View Paper
“ Melatonin also reduced the oscillatory pattern of Ca2+ mobilization evoked by a physiological concentration of CCK-8 (20 pM ), and completely inhibited Ca2+ mobilization induced by 10 pM CCK-8.”
Journal of Physiology and Biochemistry • 2013 | View Paper
“In 32% of cells, increasing melatonin concentrations in the range of 1 pM to 100 nM prolonged the latency of, and inhibited GnRH (10 nM)-stimulated [Ca2+]i increases in a concentration-dependent manner.”
Zhongguo yao li xue bao = Acta pharmacologica Sinica • 1995 | View Paper
“The addition of melatonin at 100 pM or 1 µM in the cocktail medium partially prevented the decrease in viability without PS translocation and the increase in capacitated spermatozoa from all breeds, with no significant effect on phosphotyrosine levels.”
Animals : an open access journal from MDPI • 2021 | View Paper
“In rings which were preincubated with melatonin at a concentration of 360 pM , a 56.5% reduction of effect size could be achieved (4.09 ± 1.22 mN versus 9.41 ± 1.74 mN, P < 0.0001).”